Prolactin: a pleiotropic neuroendocrine hormone

DR Grattan, IC Kokay - Journal of neuroendocrinology, 2008 - Wiley Online Library
The neuroendocrine control of prolactin secretion is unlike that of any other pituitary
hormone. It is predominantly inhibited by the hypothalamus and, in the absence of a …

Prolactin function and putative expression in the brain

EA Cabrera-Reyes, O Limón-Morales… - Endocrine, 2017 - Springer
Introduction Prolactin is a peptide hormone mainly synthetized and secreted by the anterior
pituitary gland, but also by extrapituitary tissues, such as mammary gland, decidua, prostate …

Estrogen receptor‐β, but not estrogen receptor‐α, is expressed in prolactin neurons of the female rat paraventricular and supraoptic nuclei: Comparison with other …

S Suzuki, RJ Handa - Journal of Comparative Neurology, 2005 - Wiley Online Library
Estrogen receptor‐α (ER‐α) and ER‐β exhibit fine differences in their distributions in the
rodent forebrain, and one such difference is observed in the paraventricular (PVN) and …

Expression of the long form of the prolactin receptor in magnocellular oxytocin neurons is associated with specific prolactin regulation of oxytocin neurons

IC Kokay, PM Bull, RL Davis… - American Journal of …, 2006 - journals.physiology.org
Magnocellular neurons of the supraoptic (SON) and paraventricular nuclei (PVN) show
considerable plasticity during pregnancy and lactation. Prolactin receptors (PRL-R) have …

In vivo release and gene upregulation of brain prolactin in response to physiological stimuli

L Torner, R Maloumby, G Nava… - European journal of …, 2004 - Wiley Online Library
Although prolactin (PRL) actions and expression in the brain have been shown, dynamic
changes in its intracerebral release and gene expression have still not been demonstrated …

Principles of the prolactin/vasoinhibin axis

J Triebel, T Bertsch, C Bollheimer… - American Journal …, 2015 - journals.physiology.org
The hormonal family of vasoinhibins, which derive from the anterior pituitary hormone
prolactin, are known for their inhibiting effects on blood vessel growth, vasopermeability, and …

Prolactin-derived vasoinhibins increase anxiety-and depression-related behaviors

M Zamorano, MG Ledesma-Colunga, N Adán… - …, 2014 - Elsevier
The hormone prolactin (PRL) regulates neuroendocrine and emotional stress responses. It
is found in the hypothalamus, where the protein is partially cleaved to vasoinhibins, a family …

Prolactin promotes oxytocin and vasopressin release by activating neuronal nitric oxide synthase in the supraoptic and paraventricular nuclei

C Vega, B Moreno-Carranza… - American Journal …, 2010 - journals.physiology.org
Prolactin (PRL) stimulates the secretion of oxytocin (OXT) and arginine AVP as part of the
maternal adaptations facilitating parturition and lactation. Both neurohormones are under …

Dual roles of prolactin and vasoinhibin in inflammatory arthritis

C Clapp, G Ortiz, JF García-Rodrigo… - Frontiers in …, 2022 - frontiersin.org
The term inflammatory arthritis defines a family of diseases, including rheumatoid arthritis
(RA), caused by an overactive immune system, and influenced by host aspects including …

Region-, neuron-, and signaling pathway-specific increases in prolactin responsiveness in reproductively experienced female rats

A Sjoeholm, RS Bridges, DR Grattan… - …, 2011 - academic.oup.com
Pregnancy and lactation cause long-lasting enhancements in maternal behavior and other
physiological functions, along with increased hypothalamic prolactin receptor expression. To …