The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Pyroptosis is a form of necrotic and inflammatory programmed cell death, which could be
characterized by cell swelling, pore formation on plasma membranes, and release of …

Inflammasomes are large cytosolic multiprotein complexes that assemble in response to
detection of infection-or stress-associated stimuli and lead to the activation of caspase-1 …

Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …

The innate immune system in vertebrates and invertebrates relies on conserved receptors
and ligands, and pathways that can rapidly initiate the host response against microbial …

Objectives Inflammasomes are multiprotein complexes that sense pathogens and trigger
biological mechanisms to control infection. Nucleotide-binding oligomerisation domain-like …

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are pattern-
recognition receptors similar to toll-like receptors (TLRs). While TLRs are transmembrane …

Autoimmune diseases are chronic immune diseases characterized by dysregulation of
immune system, which ultimately results in a disruption in self-antigen tolerance. Cumulative …