Basement membranes are delicate, nanoscale and pliable sheets of extracellular matrices
that often act as linings or partitions in organisms. Previously considered as passive …

The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

Perlecan, a large basement membrane heparan sulfate proteoglycan, is expressed in a
wide array of tissues where it regulates diverse cellular processes including bone formation …

Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …

Inflammation and autophagy have emerged as prominent issues in the context of
proteoglycan signaling. In particular, two small, leucine‐rich proteoglycans, biglycan and …

An extracellular matrix (ECM) is a prerequisite for multicellular life. It is adapted to tissues
and constantly undergoes changes to preserve microenvironmental homeostasis. The ECM …

Heparanase has regulatory roles in various processes, including cell communication, gene
transcription and autophagy. In addition, it is the only known mammalian endoglycosidase …

Tissue repair and fibrosis, an abnormal form of repair, occur in most human organs in
response to injury or inflammation. Fibroblasts play a major role in the normal repair process …

Heparan sulfate proteoglycan 2 (HSPG2) is an essential, highly conserved gene whose
expression influences many developmental processes including the formation of the heart …