Protein sequencing and the identification of post-translational modifications are key to
understanding cellular signalling pathways and metabolic processes in health and disease …

Despite tremendous gains over the past decade, methods for characterizing proteins have
generally lagged behind those for nucleic acids, which are characterized by extremely high …

Advances in the site-specific chemical modification of proteins, also referred to as protein
bioconjugation, have proved instrumental in revolutionary approaches to designing new …

Lysine dimethylation (Kme2) is a crucial post-translational modification (PTM) that regulates
biological processes and is implicated in diseases. There is significant interest in globally …

Site-specific protein labeling plays important roles in drug discovery and illuminating
biological processes at the molecular level. However, it is challenging to label proteins with …

Since the dependence of ferroptosis on autophagy was discovered, the cross-linking
between ferroptosis and autophagy has received much attention. Studies have shown that …

Exchanging the ribose backbone of an oligonucleotide for a peptide can enhance its
physiologic stability and nucleic acid binding affinity. Ordinarily, the eneamino nitrogen atom …

Proteins carry out life's essential functions. Comprehensive proteome analysis technologies
are thus required for a full understanding of the operating principles of biological systems …

Although chemical methods for the selective derivatization of amino acid (AA) side chains in
peptides and proteins are available, selective N-terminal labeling is challenging, especially …

The practical application of new single molecule protein sequencing (SMPS) technologies
requires accurate estimates of their associated sequencing error rates. Here, we describe …