Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

The rational choice and design of biomaterials for biomedical applications is crucial for
successful in vitro and in vivo strategies, ultimately dictating their performance and potential …

Alginate biopolymers are characterized by favorable properties, of biocompatibility,
degradability, and non-toxicity. However, the poor stability properties of alginate have limited …

Herein, a polysaccharide-based fluorescent hydrogel with multi-responsiveness simply
implemented by concurrent effects of ionic crosslinking/rehydration processes is presented …

Natural and synthetic coumarin derivatives have gained increased attention in the design of
functional polymers and polymer networks due to their unique optical, biological, and …

As a result of the biological activities of natural flavonoids, several synthetic strategies
aiming to obtain analogues with improved potency and/or pharmacokinetic profile have …

Biofunctionalization of polysaccharides is a widely used strategy for obtaining extracellular
matrix (ECM)-mimicking biomaterials. Still, commonly employed chemistries present low …

In vivo, cells interact with the extracellular matrix (ECM), which provides a multitude of
biophysical and biochemical signals that modulate cellular behavior. Inspired by this, we …

The stromal microenvironment of breast tumors, namely the vasculature, has a key role in
tumor development and metastatic spread. Tumor angiogenesis is a coordinated process …

Tissue factor (TF), an integral membrane protein, is by far the most potent known triggering
agent of blood coagulation. Inspired by TF's effectiveness in initiating coagulation, this work …