Atherosclerotic cardiovascular disease is the leading cause of death globally. Despite its
important risk of premature atherosclerosis and cardiovascular disease, familial …

Apolipoprotein E (apoE) is a major apolipoprotein involved in lipoprotein metabolism. It is a
polymorphic protein and different isoforms are associated with variations in lipid and …

Autosomal dominant familial hypercholesterolemia (FH) affects approximately 1/250,
individuals and potentially leads to elevated blood cholesterol and a significantly increased …

Background Familial hypercholesterolemia is characterised by high low-density lipoprotein-
cholesterol levels and is caused by a pathogenic variant in LDLR, APOB or PCSK9. We …

In the early 1980s, the Nobel Prize winning cellular and molecular work of Mike Brown and
Joe Goldstein led to the identification of the LDL receptor gene as the first gene where …

Familial hypercholesterolemia (FH) is a genetic disease characterized by high low-density
lipoprotein (LDL) cholesterol (LDL-c) concentrations that increase cardiovascular risk and …

Familial hypercholesterolemia (FH) is a monogenic form of severe hypercholesterolemia
that, if left untreated, is associated with early onset of atherosclerosis. FH derives from …

Familial hypercholesterolemia (FH) is associated with an elevated risk of atherosclerosis.
The finding of monogenic defects indicates higher atherosclerotic risk in comparison with …

Abstract Background and Aims: The assembly and secretion of VLDL from the liver, a
pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out …

Autosomal‐dominant familial hypercholesterolemia (FH) is characterized by increased
plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) and a substantial risk …