Alzheimer's therapeutic development: shifting neurodegeneration to neuroregeneration

MK Sun, DL Alkon - Trends in Pharmacological Sciences, 2024 - cell.com
Abstract Alzheimer's disease (AD), similar to AD-related dementias, is characterized by
impaired/lost neuronal structures and functions due to a long progression of …

Lipocalin-2 as a mediator of neuroimmune communication

R Afridi, JH Kim, A Bhusal, WH Lee… - Journal of Leukocyte …, 2024 - academic.oup.com
Abstract Lipocalin-2, a neutrophil gelatinase-associated lipocalin, is a 25-kDa secreted
protein implicated in a broad range of inflammatory diseases affecting the brain and …

Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease

P Bhattarai, TI Gunasekaran, ME Belloy… - Acta …, 2024 - Springer
The risk of developing Alzheimer's disease (AD) significantly increases in individuals
carrying the APOEε4 allele. Elderly cognitively healthy individuals with APOEε4 also exist …

ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling

H Tayran, E Yilmaz, P Bhattarai, Y Min, X Wang, Y Ma… - Cell genomics, 2024 - cell.com
Genetic variants in ABCA7, an Alzheimer's disease (AD)-associated gene, elevate AD risk,
yet its functional relevance to the etiology is unclear. We generated a CRISPR-Cas9 …

Nicotine suppresses crystalline silica‐induced astrocyte activation and neuronal death by inhibiting NF‐κB in the mouse hippocampus

H Cao, B Li, M Mu, S Li, H Chen, H Tao… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims Exposure to crystalline silica (CS) in occupational settings induces chronic
inflammation in the respiratory system and, potentially, the brain. Some workers are …

Bibliometric and visual analysis of single-cell multiomics in neurodegenerative disease arrest studies

J Wang, S Wang, Q Li, F Liu, Y Wan, H Liang - Frontiers in Neurology, 2024 - frontiersin.org
Background Neurodegenerative diseases are progressive disorders that severely diminish
the quality of life of patients. However, research on neurodegenerative diseases needs to be …

[HTML][HTML] Assessing the Neurodevelopmental Impact of Fluoxetine, Citalopram, and Paroxetine on Neural Stem Cell-Derived Neurons

K Hosseini, A Cediel-Ulloa, MH Al-Sabri, A Forsby… - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: Many pregnant women globally suffer from depression and are
routinely prescribed selective serotonin reuptake inhibitors (SSRIs). These drugs function by …

[HTML][HTML] Genetic Contributions to Recovery following Brain Trauma: A Narrative Review

D Lakshmipathy, S Rangarajan, A Barreau… - Frontiers in Bioscience …, 2024 - imrpress.com
Traumatic brain injury (TBI) is a frequently encountered form of injury that can have lifelong
implications. Despite advances in prevention, diagnosis, monitoring, and treatment, the …

Deciphering the dynamic single-cell transcriptional landscape in the ocular surface ectoderm differentiation system

C Zhang, Z Lin, Y Yu, S Wu, H Huang, Y Huang… - Life …, 2024 - academic.oup.com
The ocular surface ectoderm (OSE) is essential for the development of the ocular surface,
yet the molecular mechanisms driving its differentiation are not fully understood. In this …

Rare genetic variation in Fibronectin 1 (FN1) protects against APOEe4 in Alzheimer's disease

P Bhattarai, TI Gunasekaran, D Reyes-Dumeyer… - bioRxiv, 2024 - biorxiv.org
The risk of developing Alzheimer's disease (AD) significantly increases in individuals
carrying the APOEe4 allele. Elderly cognitively healthy individuals with APOEe4 also exist …