Recent developments in synthetic biology, combined with continued progress in systems
biology and metabolic engineering, have enabled the engineering of microorganisms to …

Isoprenoids are present in all living organisms. Formally, they are derived from the branched
C5 carbon skeleton of isoprene, and the number of repetitions of this motif, cyclization …

Isopentenyl diphosphate (IPP) is the central intermediate in the biosynthesis of isoprenoids,
the most ancient and diverse class of natural products. Two distinct routes of IPP …

The mevalonate pathway and the glyceraldehyde 3-phosphate (GAP)–pyruvate pathway are
alternative routes for the biosynthesis of the central isoprenoid precursor, isopentenyl …

The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway
has been highly conserved throughout evolution, and isoprenoids are some of the most …

Recent developments in genomics, bioinformatics, proteomics, and analytical techniques
have resulted in a more detailed and thorough understanding of the structure of the …

Isoprenoid biosynthesis is essential for cell survival. Over 35 000 isoprenoid molecules have
been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and …

Phytol (the ester-linked side-chain of chlorophyll-a) is perhaps the most studied biomarker of
those found in modern aquatic environments. This paper reviews recent studies of phytol …

Lateral gene transfer (LGT) is a major force in microbial genome evolution. Here, we present
an overview of lateral transfers affecting genes involved in isopentenyl diphosphate (IPP) …

A long-overlooked metabolic pathway for isoprenoid biosynthesis, the mevalonate-
independent methylerythritol phosphate (MEP) pathway, is present in many bacteria and in …