Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

Physical exercise is an effective therapy for neurorehabilitation. Exercise has been shown to
induce remodeling and proliferation of astrocyte. Astrocytes potentially affect the recruitment …

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare
neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene. CDD is …

New neurons are continuously generated in the adult brain through a process called adult
neurogenesis. This form of plasticity has been correlated with numerous behavioral and …

Diabetic peripheral neuropathy (DPN) is a common complication of uncontrolled diabetes.
The pathogenesis of DPN is associated with chronic inflammation in dorsal root ganglion …

Lipocalin-2 (LCN2) is a 25 kDa secreted protein that belongs to the family of lipocalins, a
group of transporters of small hydrophobic molecules such as iron, fatty acids, steroids, and …

Physical exercise (PE), notoriously, promotes a state of general well-being, throughout the
entire human lifespan. Moreover, maintaining an adequate and regular PE habit results in a …

Cell-to-cell adhesion is important for maintenance of brain structure and function. Abnormal
neuronal cell adhesion and loss of its connectivity are considered a main cause of …

In the adult mammalian brain new neurons are continuously generated throughout life in two
niches, the dentate gyrus of the hippocampus and the subventricular zone. This process …

Extracellular purines exert several functions in physiological and pathophysiological
mechanisms. ATP acts through P2 receptors as a neurotransmitter and neuromodulator and …