Functional precision medicine is a strategy whereby live tumor cells from affected individuals
are directly perturbed with drugs to provide immediately translatable, personalized …

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths
worldwide. Although advances are being made towards earlier detection and the …

Question Cystic fibrosis (CF) is due to pathogenic variants in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene. Recent improvements have enabled …

Long-term primary culture of mammalian cells has been always difficult due to unavoidable
senescence. Conventional methods for generating immortalized cell lines usually require …

The extent of genetic and epigenetic diversity between and within patient tumors is being
mapped in ever more detail. It is clear that cancer is an evolutionary process in which tumor …

Preclinical in vitro models play an important role in studying cancer cell biology and
facilitating translational research, especially in the identification of drug targets and drug …

Idiopathic pulmonary fibrosis (IPF) is a devastating fibrotic lung disease of unknown etiology
and limited therapeutic options. In this report, we characterize what we believe is a novel …

The use of advanced preclinical models has become increasingly important in drug
development. This is particularly relevant in bladder cancer, where the global burden of …

Lung cancer is the main cause of cancer death worldwide, with lung squamous cell
carcinoma (LUSC) being the second most frequent subtype. Preclinical LUSC models …

Availability of tumor and non‐tumor patient‐derived models would promote the development
of more effective therapeutics for non‐small cell lung cancer (NSCLC). Recently …