Optimization of clinical trial designs can help investigators achieve higher quality results for
the given resource constraints. The present paper gives an overview of optimal designs for …

In this paper, we present Insertus. jl, the Julia package that can help the user generate a
randomization sequence of a given length for a multi-arm trial with a pre-specified target …

Many fields including clinical and manufacturing areas usually perform life-testing
experiments and accelerated failure time models (AFT) play an essential role in these …

Artificial intelligence (AI) has come to be used in various technological fields in recent years.
However, there have been no reports of AI‐designed clinical trials. In this study, we tried to …

We introduce a framework of dose-response modeling for the evaluation of drug
combinations. We focus on adaptive techniques in dose-finding studies when several …

The exposure-response relationship of combinatory drug effects can be quantitatively
described using pharmacodynamic interaction models, which can be used for the selection …

In dose–response studies with censored time-to-event outcomes, D-optimal designs depend
on the true model and the amount of censored data. In practice, such designs can be …

Conclusions 1Department of Mathematics, Uppsala University, 2Department of
Pharmaceutical Biosciences, Uppsala University, 3Novartis Pharmaceutical Corporation. In …

Objectives: To evaluate the effect of rHu-EPO on reticulocyte production rate and age
distribution in healthy subjects. Methods: Four pharmacokinetic (PK) and pharmacodynamic …