RB1 was the first tumor suppressor gene discovered. Over 4 decades of work have revealed
that the Rb protein (Rb) is a master regulator of biological pathways influencing virtually …

Despite an enhanced permeability and retention effect typical of many solid tumors, drug
penetration is not always sufficient. Possible strategies for the drug delivery improvement …

The molecular events that precede the development of osteosarcoma, the most common
primary malignancy of bone, are unclear, and concurrent molecular and genetic alterations …

Background Epithelial-mesenchymal transition (EMT) is an early event in tumour invasion
and metastasis, and widespread and distant metastasis at early stages is the typical …

To elucidate additional phenotypic differences between large cell neuroendocrine
carcinoma (LCNEC) and small cell lung carcinoma (SCLC), we performed tissue microarray …

The susceptibility of brain to secondary formation from lung cancer primaries is a well-known
phenomenon. In contrast, the molecular basis for invasion and metastasis to the brain is …

Loss of the epithelial phenotype and disruption of adhesion molecules is a hallmark in the
epithelial–mesenchymal transition (EMT) reported in several types of cancer. Most of the …

Abstract pRb is known as a classic cell cycle regulator whose inactivation is an important
initiator of tumorigenesis. However, more recently, it has also been linked to tumor …

The aim of this study was to determine the prognostic value of α-and, β-catenin expressions
in local prostate cancer (PC). Materials and Methods: One hundred and eighty-one PC …

The retinoblastoma protein (pRb) is a cell cycle regulator inactivated in most human
cancers. Loss of pRb function results from mutations in the gene coding for pRb or for any of …