Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

One gene can give rise to many functionally distinct proteoforms, each of which has a
characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact …

Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

Oligomerization of membrane proteins in response to lipid binding has a critical role in many
cell-signalling pathways but is often difficult to define or predict. Here we report the …

G-protein-coupled receptors (GPCRs) are involved in many physiological processes and are
therefore key drug targets 1. Although detailed structural information is available for GPCRs …

β Barrel outer membrane proteins (OMPs) cluster into supramolecular assemblies that give
function to the outer membrane (OM) of Gram-negative bacteria. How such assemblies form …

Mass spectrometry is a central technology in the life sciences, providing our most
comprehensive account of the molecular inventory of the cell. In parallel with developments …

G protein-coupled receptors (GPCRs) are cell-surface receptors that respond to various
stimuli to induce signalling pathways across cell membranes. Recent progress has yielded …

Biological membranes formed of amphipathic lipid bilayers provide chemical barriers to
separate cells from their external environments and define subcellular compartments …

G-protein-coupled receptors signal through cognate G proteins. Despite the widespread
importance of these receptors, their regulatory mechanisms for G-protein selectivity are not …