Brown Spider (Loxosceles genus) Venom Toxins: Tools for Biological Purposes

OM Chaim, D Trevisan-Silva, D Chaves-Moreira… - Toxins, 2011 - mdpi.com
Venomous animals use their venoms as tools for defense or predation. These venoms are
complex mixtures, mainly enriched of proteic toxins or peptides with several, and different …

Phoneutria nigriventer venom: A pharmacological treasure

S Peigneur, ME de Lima, J Tytgat - Toxicon, 2018 - Elsevier
In millions of years, spiders have optimized their venoms in order to assure successful prey
capture and defence against predators. Spider venoms have become unique cocktails of …

[PDF][PDF] Phoneutria nigriventer venom and toxins: a review

ME De Lima, SG Figueiredo, A Matavel… - Spider …, 2015 - researchgate.net
The venom of Phoneutria nigriventer spider has been extensively studied. It is highly
neurotoxic, with clinical manifestations occurring a few minutes after the bite, mainly in …

[HTML][HTML] New insights on arthropod toxins that potentiate erectile function

KP Nunes, FS Torres, MH Borges, A Matavel… - Toxicon, 2013 - Elsevier
The use of natural substances for the treatment of diseases or injuries is an ancient practice
of many cultures. According to folklore, natural aphrodisiacs may help to raise libido and …

From the PnTx2-6 toxin to the PnPP-19 engineered peptide: Therapeutic potential in erectile dysfunction, nociception, and glaucoma

CN Silva, KP Nunes, LFN Dourado… - Frontiers in Molecular …, 2022 - frontiersin.org
The venom of the “armed” spider Phoneutria nigriventer comprises several potent toxins.
One of the most toxic components from this venom is the neurotoxin PnTx2-6 (LD50=∼ 0.7 …

Pharmacology of spider venom toxins

D Sannaningaiah, GK Subbaiah, K Kempaiah - Toxin Reviews, 2014 - Taylor & Francis
Spider venom is an intricate combination of target specific enzymatic and non-enzymatic
toxins. In addition, the venom also contains polyamine neurotoxins, ATP, AMP, ADP …

Nitric Oxide-Induced Vasorelaxation in Response to PnTx2-6 Toxin from Phoneutria nigriventer Spider in Rat Cavernosal Tissue

KP Nunes, MN Cordeiro, M Richardson… - The journal of sexual …, 2010 - academic.oup.com
Introduction Priapism is one of several symptoms observed in accidental bites by the spider
Phoneutria nigriventer. The venom of this spider is comprised of many toxins, and the …

Helminthes and insects: maladies or therapies

NL El-Tantawy - Parasitology research, 2015 - Springer
By definition, parasites cause harm to their hosts. But, considerable evidence from ancient
traditional medicine has supported the theory of using parasites and their products in …

Increased cavernosal relaxation by Phoneutria nigriventer toxin, PnTx2-6, via activation at NO/cGMP signaling

KP Nunes, BM Wynne, MN Cordeiro… - International journal of …, 2012 - nature.com
Erectile dysfunction (ED) mechanisms in diabetic patients are multifactorial and often lead to
resistance to current therapy. Animal toxins have been used as pharmacological tools to …

Erectile Function is Improved in Aged Rats by PnTx2-6, a Toxin from Phoneutria nigriventer Spider Venom

KP Nunes, HA Toque, MH Borges… - The journal of sexual …, 2012 - academic.oup.com
Introduction Age-associated erectile dysfunction (ED) involves a decrease in nitric oxide
(NO) availability and impaired relaxation. PnTx2-6, a toxin from the Phoneutria nigriventer …