Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …

The popularity of RAPTA-C in in vivo studies has steered the way for complexes of the type
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …

Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …

P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells.
P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer …

Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …

Highlights•Colchicine binding site inhibitors (CBSIs) emerge as new generations of tubulin
inhibitors.•CBSIs are less susceptible to multidrug resistance than FDA-approved tubulin …

NEDDylation, a post-translational modification through three-step enzymatic cascades,
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …

Current platinum-based drugs used in chemotherapy, like cisplatin and its derivatives, are
greatly limited due to side-effects and drug resistance. This has inspired the search for novel …

As the continuation of our work on the development of tubulin inhibitors with potential
anticancer activities, novel bis-substituted aromatic amide dithiocarbamate derivatives were …

We previously reported a potent tubulin inhibitor CH-2-77. In this study, we optimized the
structure of CH-2-77 by blocking metabolically labile sites and synthesized a series of CH-2 …