Mechanochemistry in organic synthesis: An Italian journey through innovations

F Basoccu, L De Luca… - European Journal of …, 2024 - Wiley Online Library
Mechanochemistry, as an enabling technology, harnesses mechanical force to drive
chemical reactions, presenting compelling advantages in organic synthesis within the …

Prediction of the phase diagram of liquid–liquid phase separation during crystallization via a molecular mechanism study

Y Liu, J Ouyang, X Wei, G Yu, H Shen, R Shen… - Journal of Molecular …, 2023 - Elsevier
Oiling-out is a unique liquid–liquid phase separation phenomenon in solution crystallization.
The unknown microscopic mechanism of oiling-out makes it difficult to control and …

Insight into the dissolution behavior of valsartan (form E) in twelve pure solvents: Solubility, modelling and molecular simulation

H Zhang, Y Zhang, F Xue, H Chen, Z Gao, S Du… - Journal of Molecular …, 2024 - Elsevier
Valsartan is an angiotensin II receptor antagonist used to treat hypertension. Crystals of
valsartan were prepared and the stability of the valsartan (form E) at different solvents and …

Low-Temperature Liquid–Liquid Phase Separation Strategy for In Situ Preparation of Porous Solid Lipid Microspheres Loaded with Fenofibrate Nanocrystals

S Li, D Wu, H Yu, X Huang, N Wang… - Crystal Growth & …, 2025 - ACS Publications
In this study, we successfully obtained porous trilaurin (LLL) spherical aggregates through a
simple liquid–liquid phase separation strategy (LLPS) process based on which the in situ …

Liquid-liquid equilibria of Aliquat 336+ green solvents+ water for replacement of petroleum-based solvents: Intramolecular analysis and thermodynamic behavior

N Srinam, V Mohdee, N Traiwongsa… - Journal of Industrial and …, 2024 - Elsevier
The investigations of Aliquat 336 dissolved in green solvents: corn oil, rice bran oil, and
sunflower oil, compared with toluene and kerosene to replace the petroleum-based …

Separation of 1-methoxy-2-propanol and water by organic solvent extraction based on quantum chemistry calculation and liquid-liquid equilibrium experiment

J Gao, ZJ Li, C Ding, Z Sun, Y Ma, D Xu, L Zhang… - The Journal of Chemical …, 2024 - Elsevier
Methoxy-2-propanol (PM) is extensively utilized in various industries, including coatings and
semiconductor applications, owing to its low toxicity and affordability. However, PM+ water …

Iterative model-based optimal experimental design for mixture-process variable models to predict solubility

GL Quilló, S Bhonsale, A Collas, C Xiouras… - … Research and Design, 2023 - Elsevier
Crystallization process design relies heavily on predictive solubility models. However, their
calibration is resource-and labour-intensive, especially for multicomponent solvent mixtures …

COSMO-RS prediction, experimental investigation, and mechanism analysis: A new approach to separating the n-hexane-tert-butanol azeotropic system via liquid …

Y Sheng, Q Zhang, H Xin, Z Cong, Z Zhang - Journal of Molecular Liquids, 2024 - Elsevier
Abstract n-Hexane and tert-Butanol (TBA) are frequently utilized to refine the conditions for
Grignard, Wittig, and Friedel-Crafts alkylation reactions. During the synthesis of loratadine …

Thermal decomposition kinetics, reaction mechanism, and hazard evaluation of the hydroxylamine sulfate solution doping Fe3+

X Zhang, G Tao, L Wang, J Fang, Y Xie, T Deng… - Thermochimica …, 2023 - Elsevier
To study the stability of hydroxylamine sulfate (HAS) when mixed with metal ions (especially
Fe 3+), the effect of Fe 3+ doping on the thermal decomposition of HAS was studied by …