Metabolic engineering can have a pivotal role in increasing the environmental sustainability
of the transportation and chemical manufacturing sectors. The field has already developed …

Methane is a promising feedstock with high abundance and low cost for the sustainable
production of biochemicals and biofuels. Methanotrophic bacteria are particularly interesting …

Starches, a storage form of carbohydrates, are a major source of calories in the human diet
and a primary feedstock for bioindustry. We report a chemical-biochemical hybrid pathway …

The capture of CO2 by carboxylases is key to sustainable biocatalysis and a carbon-neutral
bio-economy, yet currently limited to few naturally existing enzymes. Here, we developed …

Formate can be envisioned at the core of a carbon-neutral bioeconomy, where it is produced
from CO2 by (electro-) chemical means and converted into value-added products by …

Metabolic engineering often entails concurrent engineering of substrate utilization, central
metabolism and product synthesis pathways, inevitably creating interdependency with …

Global shift to sustainability has driven the exploration of alternative feedstocks beyond
sugars for biomanufacturing. Recently, C1 (CO2, CO, methane, formate and methanol) and …

Engineering biotechnological microorganisms to use methanol as a feedstock for
bioproduction is a major goal for the synthetic metabolism community. Here, we aim to …

Synthetic methylotrophy has recently been intensively studied to achieve methanol-based
biomanufacturing of fuels and chemicals. However, attempts to engineer platform …

Abundant natural gas reserves, along with increased biogas production, have prompted
recent interest in harnessing methane as an industrial feedstock for the production of liquid …