Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant
phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co …

Mitochondrial diseases involve the respiratory chain, which is under the dual control of
nuclear and mitochondrial DNA (mtDNA). The complexity of mitochondrial genetics provides …

Congenital muscular dystrophies (CMDs) are early onset disorders of muscle with
histological features suggesting a dystrophic process. The congenital muscular dystrophies …

The reorganization of metabolic pathways in cancer facilitates the flux of carbon and
reducing equivalents into anabolic pathways at the expense of oxidative phosphorylation …

The immediate responses to inhibition of phosphatidylcholine (PC) biosynthesis in yeast are
altered phospholipid levels, slow growth, and defects in the morphology and localization of …

There exists a phenomenon in aging research whereby early life stress can have positive
impacts on longevity. The mechanisms underlying these observations suggest a robust, long …

Mitochondria are essential components of eukaryotic cells and are involved in a diverse set
of cellular processes that include ATP production, cellular signalling, apoptosis and cell …

Autophagy, a conserved eukaryotic intracellular catabolic pathway, maintains cell
homeostasis by lysosomal degradation of cytosolic material engulfed in double membrane …

Cellular lipid synthesis and transport are governed by intricate protein networks. Although
genetic screening should contribute to deciphering the regulatory networks of lipid …

The major phospholipid present in most eukaryotic membranes is phosphatidylcholine (PC),
comprising~ 50% of phospholipid content. PC metabolic pathways are highly conserved …