Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
Cyclin E in human cancers
R Donnellan, R Chetty - The FASEB Journal, 1999 - Wiley Online Library
Regulators of the cell cycle such as cyclin E play an important part in neoplasia. The cyclin E
protein forms a partnership with a specific protein kinase. This complex phosphorylates key …
protein forms a partnership with a specific protein kinase. This complex phosphorylates key …
Imaging of EdU, an alkyne-tagged cell proliferation probe, by Raman microscopy
Click-free imaging of the nuclear localization of an alkyne-tagged cell proliferation probe,
EdU, in living cells was achieved for the first time by means of Raman microscopy. The …
EdU, in living cells was achieved for the first time by means of Raman microscopy. The …
Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration
Mitotic inheritance of the DNA methylome is a challenging task for the maintenance of cell
identity. Whether DNA methylation pattern in different genomic contexts can all be faithfully …
identity. Whether DNA methylation pattern in different genomic contexts can all be faithfully …
Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins
MK Chelbi-Alix, H de Thé - Oncogene, 1999 - nature.com
The PML protein is associated to nuclear bodies (NBs) whose functions are as yet unknown.
PML and two other NBs-associated proteins, Sp100 And ISG20 are directly induced by …
PML and two other NBs-associated proteins, Sp100 And ISG20 are directly induced by …
Sequestration and inhibition of Daxx-mediated transcriptional repression by PML
H Li, C Leo, J Zhu, X Wu, J O'Neil, EJ Park… - Molecular and cellular …, 2000 - Taylor & Francis
PML fuses with retinoic acid receptor α (RARα) in the t (15; 17) translocation that causes
acute promyelocytic leukemia (APL). In addition to localizing diffusely throughout the …
acute promyelocytic leukemia (APL). In addition to localizing diffusely throughout the …
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
S Yang, C Kuo, JE Bisi, MK Kim - Nature cell biology, 2002 - nature.com
The promyelocytic leukaemia (PML) gene is translocated in most acute promyelocytic
leukaemias and encodes a tumour suppressor protein. PML is involved in multiple apoptotic …
leukaemias and encodes a tumour suppressor protein. PML is involved in multiple apoptotic …
Raman microscopy for cellular investigations—From single cell imaging to drug carrier uptake visualization
B Kann, HL Offerhaus, M Windbergs, C Otto - Advanced drug delivery …, 2015 - Elsevier
Progress in advanced therapeutic concepts requires the development of appropriate carrier
systems for intracellular drug delivery. Consequently, analysis of interaction between …
systems for intracellular drug delivery. Consequently, analysis of interaction between …
Regulation of apoptosis by PML and the PML-NBs
The promyelocytic leukemia protein (PML) is a tumor suppressor identified in acute PML and
implicated in the pathogenesis of a variety of tumors. PML is essential for the proper …
implicated in the pathogenesis of a variety of tumors. PML is essential for the proper …
The function, regulation and therapeutic implications of the tumor suppressor protein, PML
The tumor suppressor protein, promyelocytic leukemia protein (PML), was originally
identified in acute promyelocytic leukemia due to a chromosomal translocation between …
identified in acute promyelocytic leukemia due to a chromosomal translocation between …