The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

RJ Grams, WL Santos, IR Scorei, A Abad-García… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment

P Coghi, J Li, NS Hosmane… - Medicinal Research …, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT) is one of the most promising treatments among
neutron capture therapies due to its long‐term clinical application and unequivocally …

A review of boron neutron capture therapy: Its history and current challenges

WH Jin, C Seldon, M Butkus… - … journal of particle …, 2022 - meridian.allenpress.com
Abstract Mechanism of Action External beam, whether with photons or particles, remains as
the most common type of radiation therapy. The main drawback is that radiation deposits …

Optimizing boron neutron capture therapy (BNCT) to treat cancer: an updated review on the latest developments on boron compounds and strategies

A Monti Hughes, N Hu - Cancers, 2023 - mdpi.com
Simple Summary Boron neutron capture therapy (BNCT) is a tumor-selective particle
radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation …

Tumor Eradication by Boron Neutron Capture Therapy with 10B‐enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(Glycerol)

Y Zhang, HG Kang, H Xu, H Luo, M Suzuki… - Advanced …, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high
precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10B …

Multi-functional boron-delivery agents for boron neutron capture therapy of cancers

SO Oloo, KM Smith, MGH Vicente - Cancers, 2023 - mdpi.com
Simple Summary Many boron-containing compounds have been synthesized and proposed
as boron-delivery agents for boron neutron capture therapy for cancers, including brain …

Carboranes as unique pharmacophores in antitumor medicinal chemistry

Y Chen, F Du, L Tang, J Xu, Y Zhao, X Wu, M Li… - Molecular Therapy …, 2022 - cell.com
Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of
benzene. It features special physical and chemical properties, and thus has the potential to …

Evaluation of sodium borocaptate (BSH) and boronophenylalanine (BPA) as boron delivery agents for neutron capture therapy (NCT) of cancer: an update and a …

RF Barth, N Gupta, S Kawabata - Cancer Communications, 2024 - Wiley Online Library
Boron neutron capture therapy (BNCT) is a cancer treatment modality based on the nuclear
capture and fission reactions that occur when boron‐10, a stable isotope, is irradiated with …

Clinical viability of boron neutron capture therapy for personalized radiation treatment

D Skwierawska, JA López-Valverde, M Balcerzyk… - Cancers, 2022 - mdpi.com
Simple Summary Usually, for dose planning in radiotherapy, the tumor is delimited as a
volume on the image of the patient together with other clinical considerations based on …

Importance of radiobiological studies for the advancement of boron neutron capture therapy (BNCT)

AM Hughes - Expert Reviews in Molecular Medicine, 2022 - cambridge.org
Boron neutron capture therapy (BNCT) is a tumour selective particle radiotherapy, based on
the administration of boron carriers incorporated preferentially by tumour cells, followed by …