Single-cell biology is facing a crisis of sorts. Vast numbers of single-cell molecular profiles
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …

Animals rely on their nervous systems to process sensory inputs, integrate these with
internal signals, and produce behavioral outputs. This is enabled by the highly specialized …

Despite growing knowledge of the functions of individual human transcriptional effector
domains, much less is understood about how multiple effector domains within the same …

Transcription Factor (TF) condensates are a heterogenous mix of RNA, DNA, and multiple
co-factor proteins capable of modulating the transcriptional response of the cell. The …

The nervous system is one of the most sophisticated animal tissues, consisting of thousands
of interconnected cell types. How the nervous system develops its diversity from a few neural …

The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

Proximity-dependent labeling approaches such as BioID have been a great boon to studies
of protein-protein interactions in the context of cytoskeletal structures such as centrosomes …

MicroRNAs (miRNAs) were first discovered in C. elegans as essential post-transcriptional
regulators of gene expression. Since their initial discovery, miRNAs have been implicated in …

Tight control of the transcription process is essential for the correct spatial and temporal
gene expression pattern during development and in homeostasis. Enhancers are at the core …

The Drosophila visual system supports complex behaviors and shares many of its
anatomical and molecular features with the vertebrate brain. Yet, it contains a much more …