Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively
expressed on the surface of professional antigen-presenting cells (APCs), including …

Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …

Abstract The World Health Organization, has declared the recent multiregional outbreak of
monkeypox, a global public health emergency. Monkeypox is a zoonotic viral infection …

RING finger domain and RING finger-like ubiquitin ligases (E3s), such as U-box proteins,
constitute the vast majority of known E3s. RING-type E3s function together with ubiquitin …

In metazoans, lysosomes are the center for the degradation of macromolecules and play a
key role in a variety of cellular processes, such as autophagy, exocytosis and membrane …

Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

Efficient genetic modification of herpesviruses such as Kaposi's sarcoma-associated
herpesvirus (KSHV) has come to rely on bacterial artificial chromosome (BAC) technology …

The membrane-associated RING-CH (MARCH) proteins are E3 ligases that regulate the
stability of various cellular membrane proteins. MARCH8 has been reported to inhibit the …

We identify a mitochondrial E3 ubiquitin ligase, MARCH5, as a critical regulator of
mitochondrial fission. MARCH5 RING mutants and MARCH5 RNA interference induce an …