More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Objective Fibroblast‐like synoviocytes (FLSs) are critical for promoting joint damage in
rheumatoid arthritis (RA). N 6‐methyladenosine (m6A) modification plays key roles in …

While myelodysplastic syndromes with del (5q)(del (5q) MDS) comprises a well-defined
hematological subgroup, the molecular basis underlying its origin remains unknown. Using …

The DNA methylation regulators DNMT3A and TET2 are recurrently mutated in
hematological disorders. Despite possessing antagonistic biochemical activities, loss-of …

Simple Summary Myelofibrosis is an aggressive bone marrow cancer whose clinical
presentation can be extremely heterogenous. Two distinct phenotypes, myeloproliferative …

The myeloproliferative neoplasms (MPN) frequently progress to blast phase disease, an
aggressive form of acute myeloid leukemia. To identify genes that suppress disease …

MYCN oncogene amplification is frequently observed in aggressive childhood
neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma …