Management of multi organ dysfunction in neonatal encephalopathy

M O'Dea, D Sweetman, SL Bonifacio, M El-Dib… - Frontiers in …, 2020 - frontiersin.org
Neonatal Encephalopathy (NE) describes neonates with disturbed neurological function in
the first post-natal days of life. NE is an overall term that does not specify the etiology of the …

Impact of hypothermia on predictors of poor outcome: how do we decide to redirect care?

SL Bonifacio, LS Devries, F Groenendaal - Seminars in Fetal and Neonatal …, 2015 - Elsevier
Therapeutic hypothermia is now considered the standard of care for neonates with neonatal
encephalopathy due to perinatal asphyxia. Outcomes following hypothermia treatment are …

Cerebrospinal fluid levels of neuron-specific enolase predict the severity of brain damage in newborns with neonatal hypoxic-ischemic encephalopathy treated with …

MZ León-Lozano, J Arnaez, A Valls, G Arca, T Agut… - PLoS …, 2020 - journals.plos.org
Objectives To investigate whether cerebrospinal fluid levels of neuron-specific enolase (CSF-
NSE) during the first 72 hours correlate with other tools used to assess ongoing brain …

Early identification of brain injury in infants with hypoxic ischemic encephalopathy at high risk for severe impairments: accuracy of MRI performed in the first days of life

T Agut, M León, M Rebollo, J Muchart, G Arca… - BMC pediatrics, 2014 - Springer
Abstract Background Despite therapeutic hypothermia 30-70% of newborns with moderate
or severe hypoxic ischemic encephalopathy will die or survive with significant long-term …

Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: A scoping review

M Joshi, J Muneer, L Mbuagbaw, I Goswami - Plos one, 2023 - journals.plos.org
Background Therapeutic hypothermia (TH) is a widely practiced neuroprotective strategy for
neonates with hypoxic-ischemic encephalopathy. Induced hypothermia is associated with …

Temporal trends in the severity and mortality of neonatal hypoxic-ischemic encephalopathy in the era of hypothermia

C Vega-Del-Val, J Arnaez, S Caserío, EP Gutiérrez… - Neonatology, 2021 - karger.com
Introduction: There is a paucity of studies examining temporal trends in the incidence and
mortality of moderate-to-severe hypoxic-ischemic encephalopathy (HIE) during the last …

Electroencephalography and brain magnetic resonance imaging in asphyxia comparing cooled and non-cooled infants

ATT Leen, S Ouwehand, M Olsthoorn, P Govaert… - european journal of …, 2019 - Elsevier
Objective The aim was to establish any differences in the predictive value of EEG and MRI
for outcome in infants treated and not-treated with therapeutic hypothermia (HT) for perinatal …

[HTML][HTML] La bioética en el final de la vida en neonatología: cuestiones no resueltas

J Arnaez, JC Tejedor, S Caserío, MT Montes… - Anales de …, 2017 - Elsevier
El presente documento es fruto del trabajo previo realizado por diferentes grupos de
expertos y presentado a debate multidisciplinar en unas jornadas sobre aspectos …

A failed attempt to conduct an individual patient data meta-analysis

GJ Jaspers, PLJ Degraeuwe - Systematic reviews, 2014 - Springer
A study-level meta-analysis has shown that proton magnetic resonance spectroscopy is a
promising prognostic marker in neonatal hypoxic-ischemic encephalopathy. An individual …

Neuron-specific enolase in cerebrospinal fluid predicts brain injury after sudden unexpected postnatal collapse

CM Echeverría-Palacio, T Agut, J Arnaez, A Valls… - Pediatric …, 2019 - Elsevier
Background Biomarkers of brain injury with high predictive value in newborns in critical
neurological status are increasingly required. Neuron-specific enolase in cerebrospinal fluid …