Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy

P Koutsifeli, U Varma, LJ Daniels, M Annandale… - Journal of Biological …, 2022 - ASBMB
Autophagy is an essential cellular process involving degradation of superfluous or defective
macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be …

Incomplete autophagy: Trouble is a friend

Q Zhang, S Cao, F Qiu, N Kang - Medicinal Research Reviews, 2022 - Wiley Online Library
Incomplete autophagy is an impaired self‐eating process of intracellular macromolecules
and organelles in which accumulated autophagosomes do not fuse with lysosomes for …

A new perspective on the autophagic and non-autophagic functions of the GABARAP protein family: a potential therapeutic target for human diseases

J Chen, H Zhao, M Liu, L Chen - Molecular and Cellular Biochemistry, 2024 - Springer
Mammalian autophagy-related protein Atg8, including the LC3 subfamily and GABARAP
subfamily. Atg8 proteins play a vital role in autophagy initiation, autophagosome formation …

Structure of the human autophagy factor EPG5 and the molecular basis of its conserved mode of interaction with Atg8-family proteins

YWS Cheung, SE Nam, GMJ Fairlie, K Scheu, JM Bui… - Autophagy, 2024 - Taylor & Francis
The multi-step macroautophagy/autophagy process ends with the cargo-laden
autophagosome fusing with the lysosome to deliver the materials to be degraded. The …

Molecular Mechanism of Autophagosome–Lysosome Fusion in Mammalian Cells

PY Ke - Cells, 2024 - mdpi.com
In eukaryotes, targeting intracellular components for lysosomal degradation by autophagy
represents a catabolic process that evolutionarily regulates cellular homeostasis. The …

Secretory autophagy forges a therapy resistant microenvironment in melanoma

SO Bustos, N Leal Santos, R Chammas, LNS Andrade - Cancers, 2022 - mdpi.com
Simple Summary Tumor microenvironment (TME) is a complex of many cell types and
extracellular matrix that play an active role in regulating and sustaining melanoma tumor …

Molecular structures and function of the autophagosome-lysosome fusion machinery

J Diao, CK Yip, Q Zhong - Autophagy Reports, 2024 - Taylor & Francis
Macroautophagy (also known as autophagy) plays a pivotal role in maintaining cellular
homeostasis. The terminal step of the multi-step autophagy degradation pathway involves …

The role of ectopic P granules protein 5 homolog (EPG5) in DHPG‐induced pain sensitization in mice

X Mei, C Yin, Y Pan, L Chen, C Wu… - Journal of …, 2023 - Wiley Online Library
Nociplastic pain is a severe health problem, while its mechanisms are still unclear.(R, S)‐3,
5‐Dihydroxyphenylglycine (DHPG) is a group I metabotropic glutamate receptor (mGluR) …

DYNATE: Localizing rare‐variant association regions via multiple testing embedded in an aggregation tree

X Li, J Pura, A Allen, K Owzar, J Lu… - Genetic …, 2024 - Wiley Online Library
Rare‐variants (RVs) genetic association studies enable researchers to uncover the variation
in phenotypic traits left unexplained by common variation. Traditional single‐variant analysis …

Vici syndrome in Israel: Clinical and molecular insights

O Chorin, Y Hirsch, R Rock, L Salzer Sheelo… - Frontiers in …, 2022 - frontiersin.org
Introduction: Vici Syndrome is a rare, severe, neurodevelopmental/neurodegenerative
disorder with multi-systemic manifestations presenting in infancy. It is mainly characterized …