Animal models are indispensable tools for Alzheimer disease (AD) research. Over the
course of more than two decades, an increasing number of complementary rodent models …

Senescence accelerated mice P8 (SAMP8) show significant age‐related deteriorations in
memory and learning ability in accordance with early onset and rapid advancement of …

Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been
reported to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation …

Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no
effective treatment is available for AD. Analysis of transgenic mouse models of AD has …

Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by
amyloid-beta (Aβ) deposition and neurofibrillary tangles. Numerous microRNAs have been …

The senescence accelerated mouse (SAMP8) is a spontaneous animal model of
overproduction of amyloid precursor protein (APP) and oxidative damage. It develops early …

The SAM strains, a group of related inbred strains consisting of senescence-prone inbred
strains (SAMP) and senescence-resistant inbred strains (SAMR), have been successfully …

Abstract Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disease. In the past decades, numbers of promising drug candidates …

Stem cells have emerged as a potential therapy for a range of neural insults, but their
application in Alzheimer's disease (AD) is still limited and the mechanisms underlying the …

Alzheimer's disease (AD) is a mostly sporadic brain disorder characterized by cognitive
decline resulting from selective neurodegeneration in the hippocampus and cerebral cortex …