A comprehensive review on the role of the gut microbiome in human neurological disorders

SG Sorboni, HS Moghaddam… - Clinical microbiology …, 2022 - Am Soc Microbiol
The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

Gut liver brain axis in diseases: the implications for therapeutic interventions

M Yan, S Man, B Sun, L Ma, L Guo, L Huang… - Signal Transduction and …, 2023 - nature.com
Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

[HTML][HTML] BI 456906: discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy

T Zimmermann, L Thomas, T Baader-Pagler… - Molecular …, 2022 - Elsevier
Objective Obesity and its associated comorbidities represent a global health challenge with
a need for well-tolerated, effective, and mechanistically diverse pharmaceutical …

Short-chain fatty acids—a product of the microbiome and its participation in two-way communication on the microbiome-host mammal line

O Lange, M Proczko-Stepaniak, A Mika - Current obesity reports, 2023 - Springer
Abstract Purpose of Review The review aims to describe short-chain fatty acids (SCFAs) as
metabolites of bacteria, their complex influence on whole-body metabolism, and alterations …

Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake

S Hamamah, A Amin, AL Al-Kassir, J Chuang… - Nutrients, 2023 - mdpi.com
Obesity is a multifactorial disease that continues to increase in prevalence worldwide.
Emerging evidence has shown that the development of obesity may be influenced by …

Bile acids, gut microbiota and metabolic surgery

J Tu, Y Wang, L Jin, W Huang - Frontiers in Endocrinology, 2022 - frontiersin.org
Metabolic surgery, or bariatric surgery, is currently the most effective approach for treating
obesity and its complications. Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric …

Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review

VJ Clemente-Suárez, AI Beltrán-Velasco… - Nutrients, 2023 - mdpi.com
This comprehensive narrative review explores the concept of neuro-vulnerability in energy
metabolism regulation and its implications for metabolic disorders. The review highlights the …

Dietary pulses as a means to improve the gut microbiome, inflammation, and appetite control in obesity

HS John, É Doucet, KA Power - Obesity Reviews, 2023 - Wiley Online Library
A dysbiotic intestinal microbiome has been linked to chronic diseases such as obesity,
which may suggest that interventions that target the microbiome may be useful in treating …

Binary effects of gynostemma gold nanoparticles on obesity and inflammation via downregulation of PPARγ/CEPBα and TNF-α gene expression

R Akter, L Ling, EJ Rupa, J KyuPark, R Mathiyalagan… - Molecules, 2022 - mdpi.com
Nanoscience is a multidisciplinary skill with elucidated nanoscale particles and their
advantages in applications to various fields. Owing to their economical synthesis …

Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity

SA Kleftaki, S Simati, C Amerikanou, A Gioxari… - Pharmacological …, 2022 - Elsevier
The aim of this study was to examine potential postprandial benefits of Pleurotus eryngii in
nineteen volunteers with metabolically unhealthy obesity. An acute, randomized, crossover …