Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

Several attempts have been made to treat Alzheimer's disease (AD) using anti-amyloid
strategies with disappointing results. It is clear that the “amyloid cascade hypothesis” alone …

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder,
is the leading cause of dementia in late adult life. Pathologically it is characterized by …

Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

Alzheimer disease (AD) is the most common cause of dementia in people over 60 years old.
The molecular and cellular alterations that trigger this disease are still diffuse, one of the …

The amyloid cascade hypothesis is widely accepted as the centerpiece of Alzheimer
disease (AD) pathogenesis. It proposes that abnormal production of beta amyloid protein …

The dynamic and multicellular processes of neuroinflammation are mediated by the
nonneuronal cells of the central nervous system, which include astrocytes and the brain's …

The identification of microglia-associated, neurological disease-causing mutations in
patients, combined with studies in mouse models has highlighted microglia, the brain's …

Abstract Alzheimer's disease (AD), the most common progressive neurodegenerative
disorder is characterized by the formation of extracellular amyloid plaques and intracellular …