Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Chronic restraint stress leads to increases in brain derived neurotrophic factor (BDNF)
mRNA and protein in some regions of the brain, eg the basal lateral amygdala (BLA) but …

Stress is a major risk factor in the onset of several neuropsychiatric disorders including
anxiety and depression. Although several studies have shown that social isolation stress …

In this review, we provide a brief summary of several key studies that broaden our
understanding of stress and its epigenetic control of the function and behavior of the …

Objectives: This study sought to determine an aggregate, pathway-specific risk score for
enhanced prediction of death and myocardial infarction (MI). Background: Activation of …

Stress is defined as a disruption of the body homeostasis in response to modest as well as
perceived challenge. Two main physiological routes, the hypothalamic–pituitary–adrenal …

Icariin, a flavonoid and a major constituent of Herba Epimedii, has been previously
demonstrated to possess potential antidepressant-like effects. In the present study, we …

Background Acetylation of heat shock protein 90 (Hsp90) regulates downstream hormone
signaling via the glucocorticoid receptor (GR), but the role of this molecular mechanism in …

Background Post-stroke depression (PSD) is the most common neuropsychiatric
complication after stroke, seriously affecting the quality of survivors' life. As one of the …

We have previously reported reduced glucocorticoid receptor (GR) mRNA levels in the
hippocampus and hypothalamic paraventricular nucleus (PVN) during repeated …