Advances in dry eye disease treatment

EC O'Neil, M Henderson… - Current opinion in …, 2019 - journals.lww.com
Clinicians have more options at their disposal in the treatment of dry eye disease than ever
before, including topical medications and devices. SYNOPSIS In this article, we review …

Role of corneal nerves in ocular surface homeostasis and disease

M Labetoulle, C Baudouin, M Calonge… - Acta …, 2019 - Wiley Online Library
Corneal nerves are key components of the physiological system that controls ocular surface
homeostasis. The cornea is primarily innervated by the ophthalmic branch of the trigeminal …

Platelet-rich plasma in osteoarthritis treatment: review of current evidence

L Gato-Calvo, J Magalhaes… - … advances in chronic …, 2019 - journals.sagepub.com
Platelet-rich plasma (PRP) is defined as a volume of plasma with a platelet concentration
higher than the average in peripheral blood. Many basic, preclinical and even clinical case …

Autologous fibrin scaffolds: When platelet-and plasma-derived biomolecules meet fibrin

E Anitua, P Nurden, R Prado, AT Nurden, S Padilla - Biomaterials, 2019 - Elsevier
The healing of vascularized mammalian tissue injuries initiate with hemostasis and clotting
as part of biological defense system leading to the formation of a fibrin clot in which activated …

Dry eye syndrome: comprehensive etiologies and recent clinical trials

R Huang, C Su, L Fang, J Lu, J Chen… - International …, 2022 - Springer
Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than
ever given the rapid pace of modernization, which is directly associated with many of the …

Corneal ulcer in dogs and cats: novel clinical application of regenerative therapy using subconjunctival injection of autologous platelet-rich plasma

HA Farghali, NA AbdElKader, HO AbuBakr… - Frontiers in veterinary …, 2021 - frontiersin.org
Background: Corneal ulcer could be a major source of distress in small animals, with many
contributing agents. In recent years, few studies evaluated the efficacy of platelet-rich …

Comparison of epitheliotrophic factors in platelet-rich plasma versus autologous serum and their treatment efficacy in dry eye disease

C Metheetrairut, P Ngowyutagon, A Tunganuntarat… - Scientific reports, 2022 - nature.com
Current treatment of severe dry eye disease (DED) includes blood-derived eye drops, such
as autologous serum (AS), which lubricate the eyes and provide factors that improve ocular …

Dry eye: why artificial tears are not always the answer

M Kim, Y Lee, D Mehra, AL Sabater… - BMJ open …, 2021 - bmjophth.bmj.com
Dry eye disease (DED) is a multifactorial disease that manifests in patients with a variety of
symptoms and signs such as ocular pain, visual issues, rapid tear evaporation and/or …

Reflections on dry eye syndrome treatment: therapeutic role of blood products

VJ Drew, CL Tseng, J Seghatchian, T Burnouf - Frontiers in medicine, 2018 - frontiersin.org
Dry eye syndrome (DES) is a multifactorial, frequent, pathology characterized by deficient
tear production or increased evaporation of tears and associated with ocular surface …

Tivanisiran, a novel siRNA for the treatment of dry eye disease

J Moreno-Montañés, AM Bleau… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Dry eye disease (DED) is characterized by an alteration of the tear film with
ocular inflammation and neurosensory abnormalities. The main clinical signs of this …