Natural products as anticancer agents: current status and future perspectives

A Naeem, P Hu, M Yang, J Zhang, Y Liu, W Zhu… - Molecules, 2022 - mdpi.com
Natural products have been an invaluable and useful source of anticancer agents over the
years. Several compounds have been synthesized from natural products by modifying their …

Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials

AK Tripathi, AK Ray, SK Mishra - Beni-Suef university journal of basic and …, 2022 - Springer
Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like
antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective …

Natural products/bioactive compounds as a source of anticancer drugs

ST Asma, U Acaroz, K Imre, A Morar, SRA Shah… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is considered as a large group of diseases involving abnormal cell
growth, which results in an alarming rise in the mortality rate at the worldwide level …

Anticancer applications and pharmacological properties of piperidine and piperine: a comprehensive review on molecular mechanisms and therapeutic perspectives

S Mitra, U Anand, NK Jha, MS Shekhawat… - Frontiers in …, 2022 - frontiersin.org
Piperine and piperidine are the two major alkaloids extracted from black pepper (Piper
nigrum); piperidine is a heterocyclic moiety that has the molecular formula (CH2) 5NH. Over …

Piperidine nucleus in the field of drug discovery

MM Abdelshaheed, IM Fawzy, HI El-Subbagh… - Future Journal of …, 2021 - Springer
Background Piperidine is an essential heterocyclic system and a pivotal cornerstone in the
production of drugs. Piperidine byproducts showed several important pharmacophoric …

Role of plant-derived active constituents in cancer treatment and their mechanisms of action

AW Khan, M Farooq, M Haseeb, S Choi - Cells, 2022 - mdpi.com
Despite significant technological advancements in conventional therapies, cancer remains
one of the main causes of death worldwide. Although substantial progress has been made …

Mechanisms of action of fruit and vegetable phytochemicals in colorectal cancer prevention

T Alzate-Yepes, L Pérez-Palacio, E Martínez, M Osorio - Molecules, 2023 - mdpi.com
Colorectal cancer (CRC) is the third most common cancer worldwide and its incidence is
expected to increase by almost 80% by 2030. CRC apparition is related to poor diet, mainly …

The promise of Piperine in cancer chemoprevention

S Benayad, H Wahnou, R El Kebbaj, B Liagre, V Sol… - Cancers, 2023 - mdpi.com
Simple Summary With 19.3 million new cancer cases worldwide and nearly 10.0 million
cancer-related deaths cancer is a global health challenge. Cancer is a disease caused by a …

Flavones: Six selected flavones and their related signaling pathways that induce apoptosis in cancer

SH Jeong, HH Kim, SE Ha, MY Park… - International Journal of …, 2022 - mdpi.com
Cancer is a horrific disease that, to date, has no cure. It is caused by various factors and
takes many lives. Apoptosis is a programmed cell death mechanism and if it does not …

Pectin coated nanostructured lipid carriers for targeted piperine delivery to hepatocellular carcinoma

EMM Shehata, MA Gowayed, SO El-Ganainy… - International Journal of …, 2022 - Elsevier
Piperine (PIP) is a herbal drug with well-known anticancer activity against different types of
cancer including hepatocellular carcinoma. However, low aqueous solubility and extensive …