The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

Cardiovascular disease (CVD) has become a severe threat to human health, with morbidity
and mortality increasing yearly and gradually becoming younger. When the disease …

The epicardium, the outermost layer of the heart, is an important regulator of cardiac
regeneration. However, a detailed understanding of the crosstalk between the epicardium …

The Wilms' tumor suppressor WT1 is essential for the development of the heart, among other
organs such as the kidneys and gonads. The Wt1 gene encodes a zinc finger transcription …

Receptors for activated C kinases (RACKs) have been shown to coordinate PKC-mediated
hypertrophic signalling in mice. However, little information is available on its participation in …

The epicardium is a very dynamic cardiac layer with pivotal contributions during
cardiogenesis, acting in the postnatal period as an apparently dormant single-cell layer. In …

Fish are increasingly used as experimental animals across research fields. Currently,
around a quarter of all experimental animals used are fish. Less than 20% of these are …

Autophagy-lysosomal degradation is an evolutionarily conserved process key to cellular
homeostasis, differentiation, and stress survival, which is particularly important for the …

During heart development, the embryonic ventricle becomes enveloped by the epicardium,
which adheres to the outer apical surface of the heart. This is concomitant with onset of …

Cellular senescence is a natural biological process characterized by a permanent and
irreversible state of cellular arrest, mitochondrial alteration, and secretion of senescence …