Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …

Noncoding RNAs (ncRNAs) function with associated proteins to effect complex structural
and regulatory outcomes. To reveal the composition and dynamics of specific noncoding …

Epigenetic enzymes are often dysregulated in human tumors through mutation, altered
expression, or inappropriate recruitment to certain loci. The identification of these enzymes …

Abstract In 1964, Vincent Allfrey and colleagues reported the identification of histone
acetylation and with deep insight proposed a regulatory role for this protein modification in …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

Cells of a multicellular organism are genetically homogeneous but structurally and
functionally heterogeneous owing to the differential expression of genes. Many of these …

Oxidative stress and the resulting damage to genomic DNA are inevitable consequences of
endogenous physiological processes, and they are amplified by cellular responses to …

Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …