[HTML][HTML] The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease

G Oliver, J Kipnis, GJ Randolph, NL Harvey - Cell, 2020 - cell.com
Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

Pathophysiology of Crohn's disease inflammation and recurrence

L Petagna, A Antonelli, C Ganini, V Bellato… - Biology direct, 2020 - Springer
Chron's Disease is a chronic inflammatory intestinal disease, first described at the beginning
of the last century. The disease is characterized by the alternation of periods of flares and …

Location is important: differentiation between ileal and colonic Crohn's disease

R Atreya, B Siegmund - Nature Reviews Gastroenterology & …, 2021 - nature.com
Crohn's disease can affect any part of the gastrointestinal tract; however, current European
and national guidelines worldwide do not differentiate between small-intestinal and colonic …

Novel mechanisms and clinical trial endpoints in intestinal fibrosis

J Wang, S Lin, JM Brown, D van Wagoner… - Immunological …, 2021 - Wiley Online Library
The incidence of inflammatory bowel diseases (IBD) worldwide has resulted in a global
public health challenge. Intestinal fibrosis leading to stricture formation and bowel …

Small bowel Crohn disease at CT and MR enterography: imaging atlas and glossary of terms

FF Guglielmo, SA Anupindi, JG Fletcher… - Radiographics, 2020 - pubs.rsna.org
Representatives from the Society of Abdominal Radiology Crohn's Disease–Focused Panel,
the Society for Pediatric Radiology, the American Gastroenterological Association, and other …

Mechanism of fibrosis and stricture formation in Crohn's disease

J Alfredsson, MJ Wick - Scandinavian Journal of Immunology, 2020 - Wiley Online Library
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract that
leads to substantial suffering for millions of patients. In some patients, the chronic …

Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor

RS Czepielewski, EC Erlich, EJ Onufer, S Young… - Immunity, 2021 - cell.com
Lymphangitis and the formation of tertiary lymphoid organs (TLOs) in the mesentery are
features of Crohn's disease. Here, we examined the genesis of these TLOs and their impact …

Development of antifibrotic therapy for stricturing Crohn's disease: lessons from randomized trials in other fibrotic diseases

SN Lin, R Mao, C Qian, D Bettenworth… - Physiological …, 2022 - journals.physiology.org
Intestinal fibrosis is considered an inevitable complication of Crohn's disease (CD) that
results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment …

Role of gut microbiota in Crohn's disease pathogenesis: Insights from fecal microbiota transplantation in mouse model

Q Wu, LW Yuan, LC Yang, YW Zhang… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
BACKGROUND Inflammatory bowel disease, particularly Crohn's disease (CD), has been
associated with alterations in mesenteric adipose tissue (MAT) and the phenomenon termed …

[HTML][HTML] Obesity and novel management of inflammatory bowel disease

JH Kim, CM Oh, JH Yoo - World Journal of Gastroenterology, 2023 - ncbi.nlm.nih.gov
Obesity is prevalent within the inflammatory bowel disease (IBD) population, particularly in
newly developed countries. Several epidemiological studies have suggested that 15%-40 …