Hair follicle (HF) formation in developing embryonic skin requires stepwise signalling
between the epithelial epidermis and mesenchymal dermis, and their specialized …

Autotaxin (ATX), or ecto-nucleotide pyrophosphatase/phosphodiesterase-2, is a secreted
lysophospholipase D (lysoPLD) that hydrolyzes extracellular lysophospholipids into the lipid …

Defining the unique molecular features of progenitors and their niche requires a genome-
wide, whole-tissue approach with cellular resolution. Here, we co-isolate embryonic hair …

Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate
from lysophosphatidylcholine, the most abundant phospholipid in blood plasma …

Broad dermal Wnt signaling is required for patterned induction of hair follicle placodes and
subsequent Wnt signaling in placode stem cells is essential for induction of dermal …

Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …

Objective We previously implicated the lipid mediator lysophosphatidic acid (LPA) as having
a role in dermal fibrosis in systemic sclerosis (SSc). The aim of this study was to identify the …

Mesenchymal condensation is a critical step in organogenesis, yet the underlying molecular
and cellular mechanisms remain poorly understood. The hair follicle dermal condensate is …

Within the hair follicle (HF) niche, dermal papilla (DP) cells are well known for the hair
induction capacity; however, DP cell signaling also regulates HF pigmentation. Here we …

Extracellular lysophosphatidate (LPA) is a potent bioactive lipid that signals through six G-
protein-coupled receptors. This signaling is required for embryogenesis, tissue repair and …