Significance: Mitochondria, vital cellular power plants to generate energy, are involved in
immune responses. Mitochondrial damage-associated molecular patterns (DAMPs) are …

The mitochondrion is an intracellular organelle thought to originate from endosymbiosis
between an ancestral eukaryotic cell and an α-proteobacterium. Mitochondria are the …

Red blood cells (RBCs) are essential for aerobic respiration through delivery of oxygen to
distant tissues. However, RBCs are currently considered immunologically inert, and few, if …

Background Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate
immune system. However, mtDNA level has not been tested for its role as a biomarker in the …

Mitochondrial components, including mitochondrial DNA (mtDNA), when released
extracellularly, can act as “damage‐associated molecular pattern”(DAMP) agents and cause …

Among the complex determinants of aging, mitochondrial dysfunction has been in the
spotlight for a long time. As the hub for many cellular functions, the maintenance of an …

Mitochondria are negatively affected by ageing leading to their inability to adapt to higher
levels of oxidative stress and this ultimately contributes to the systemic loss of muscle mass …

Fragments of mitochondrial DNA (mtDNA) are released outside the cell and they appear to
persist in extracellular fluids as circulating, cell-free, mtDNA (ccf-mtDNA). When compared to …

Mitochondrial DNA (mtDNA) has many similarities with bacterial DNA because of their
shared common ancestry. Increasing evidence demonstrates mtDNA to be a potent danger …

Background. Sepsis is associated with mitochondrial dysfunction and impaired oxygen
consumption, which may condition clinical outcome independent of tissue oxygenation …