Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

In the past 65 years, antifolates targeting folate metabolism played a pivotal role in drug
treatment of malignant, microbial, parasitic and chronic inflammatory diseases. Drug …

Breast cancer resistance protein (BCRP)/ATP-binding cassette subfamily G member 2
(ABCG2) is an ATP-binding cassette (ABC) transporter identified as a molecular cause of …

Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …

Human ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily and
is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC …

Antifolates are structural analogs of folates, essential one-carbon donors in the synthesis of
DNA in mammalian cells. Antifolates are inhibitors of key enzymes in folate metabolism …

Members of the ATP-binding cassette (ABC) transporters including P-glycoprotein
(Pgp/ABCB1), multidrug resistance proteins (MRPs/ABCC) as well as breast cancer …

Multi-drug chemoresistance remains one of the most common reasons for chemotherapy
failure. The membrane transporter protein ABCG2/BCRP1 has been shown in vitro to …

Acyldepsipeptides (ADEPs) are potential antibiotics that dysregulate the activity of the highly
conserved tetradecameric bacterial ClpP protease, leading to bacterial cell death. Here, we …