[HTML][HTML] Lung parenchymal mechanics

B Suki, D Stamenovic, R Hubmayr - Comprehensive Physiology, 2011 - ncbi.nlm.nih.gov
The lung parenchyma comprises a large number of thin-walled alveoli, forming an
enormous surface area, which serves to maintain proper gas exchange. The alveoli are held …

Oscillation mechanics of the respiratory system

JHT Bates, CG Irvin, R Farré… - Comprehensive …, 2011 - Wiley Online Library
The mechanical impedance of the respiratory system defines the pressure profile required to
drive a unit of oscillatory flow into the lungs. Impedance is a function of oscillation frequency …

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

MSD Kormann, G Hasenpusch, MK Aneja, G Nica… - Nature …, 2011 - nature.com
Current viral vectors for gene therapy,, are associated with serious safety concerns,
including leukemogenesis, and nonviral vectors are limited by low gene transfer efficiency …

The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza

M Morita, K Kuba, A Ichikawa, M Nakayama, J Katahira… - Cell, 2013 - cell.com
Influenza A viruses are a major cause of mortality. Given the potential for future lethal
pandemics, effective drugs are needed for the treatment of severe influenza such as that …

Vitamin D deficiency causes deficits in lung function and alters lung structure

GR Zosky, LJ Berry, JG Elliot, AL James… - American journal of …, 2011 - atsjournals.org
Rationale: The prevalence of vitamin D deficiency is increasing and has been linked to
obstructive lung diseases including asthma and chronic obstructive pulmonary disease …

CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin

A Ichikawa, K Kuba, M Morita, S Chida… - American journal of …, 2013 - atsjournals.org
Rationale: Patients who developed acute respiratory distress syndrome (ARDS) after
infection with severe respiratory viruses (eg, severe acute respiratory syndrome …

Rna with a combination of unmodified and modified nucleotides for protein expression

C Rudolph, M Kormann - US Patent App. 13/388,140, 2012 - Google Patents
The invention relates to a polyribonucleotide with a sequence that codes a protein or protein
fragment, wherein the polyri bonucleotide comprises a combination of unmodified and …

The effects of electronic cigarette aerosol exposure on inflammation and lung function in mice

AN Larcombe, MA Janka, BJ Mullins… - … of Physiology-Lung …, 2017 - journals.physiology.org
Electronic cigarette usage is increasing worldwide, yet there is a paucity of information on
the respiratory health effects of electronic cigarette aerosol exposure. This study aimed to …

Tumor necrosis factor–α overexpression in lung disease: a single cause behind a complex phenotype

LKA Lundblad, J Thompson-Figueroa… - American journal of …, 2005 - atsjournals.org
Rationale: Tumor necrosis factor α (TNF-α) has been implicated as a key cytokine in many
inflammatory lung diseases. These effects are currently unclear, because a transgenic …

Lung parenchymal mechanics in health and disease

DS Faffe, WA Zin - Physiological reviews, 2009 - journals.physiology.org
The mechanical properties of lung tissue are important determinants of lung physiological
functions. The connective tissue is composed mainly of cells and extracellular matrix, where …