Leishmania, the causative agent of leishmaniases, is an intracellular parasite of
macrophages, transmitted to humans via the bite of its sand fly vector. This protozoan …

G protein‐coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across cell membranes and represent major targets in the development of …

Leishmaniasis is a neglected parasitic disease for which the current antileishmania
therapeutics are hampered by drug toxicity, high cost, need for parenteral administration …

Macrophages represent the primary human host response to pathogen infection and link the
immediate defense to the adaptive immune system. Mature tissue macrophages convert …

Endocytosis and intracellular trafficking constitute important regulatory features associated
with G protein-coupled receptor (GPCR) function. GPCR endocytosis involves several …

Previous work from us and others has suggested that cholesterol is an important lipid in the
context of the organization of the actin cytoskeleton. However, reorganization of the actin …

Leishmania spp., transmitted to humans by the bite of the sandfly vector, are responsible for
the three major forms of leishmaniasis, cutaneous, diffuse mucocutaneous and visceral …

Leishmania donovani is an intracellular protozoan parasite that causes visceral
leishmaniasis, a major cause of mortality and morbidity worldwide. The host plasma …

Leishmaniasis is a complex of parasitic protozoan diseases caused by more than 20
different species of parasites from Leishmania genus. Conventional treatments are high …

The cellular plasma membrane serves as a portal for the entry of intracellular pathogens. An
essential step for an intracellular pathogen to gain entry into a host cell therefore is to be …