The role of liver zonation in physiology, regeneration, and disease
R Panday, CP Monckton… - Seminars in liver …, 2022 - thieme-connect.com
As blood flows from the portal triad to the central vein, cell-mediated depletion establishes
gradients of soluble factors such as oxygen, nutrients, and hormones, which act through …
gradients of soluble factors such as oxygen, nutrients, and hormones, which act through …
Engineered liver platforms for different phases of drug development
BR Ware, SR Khetani - Trends in biotechnology, 2017 - cell.com
Drug-induced liver injury (DILI) remains a leading cause of drug withdrawal from human
clinical trials or the marketplace. Owing to species-specific differences in liver pathways …
clinical trials or the marketplace. Owing to species-specific differences in liver pathways …
Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems
FT Lee-Montiel, SM George… - Experimental …, 2017 - journals.sagepub.com
This article describes our next generation human Liver Acinus MicroPhysiology System
(LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 …
(LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 …
Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes
An important number of healthy and diseased tissues shows spatial variations in their
metabolic capacities across the tissue. The liver is a prime example of such heterogeneity …
metabolic capacities across the tissue. The liver is a prime example of such heterogeneity …
On-chip construction of liver lobules with self-assembled perfusable hepatic sinusoid networks
S Ya, W Ding, S Li, K Du, Y Zhang, C Li… - … Applied Materials & …, 2021 - ACS Publications
Although various liver chips have been developed using emerging organ-on-a-chip
techniques, it remains an enormous challenge to replicate the liver lobules with self …
techniques, it remains an enormous challenge to replicate the liver lobules with self …
In vitro metabolic zonation through oxygen gradient on a chip
Among the multiple metabolic signals involved in the establishment of the hepatic zonation,
oxygen could play a key role. Indeed, depending on hepatocyte position in the hepatic …
oxygen could play a key role. Indeed, depending on hepatocyte position in the hepatic …
Progressive hypoxia‐on‐a‐chip: An in vitro oxygen gradient model for capturing the effects of hypoxia on primary hepatocytes in health and disease
YB Kang, J Eo, B Bulutoglu… - Biotechnology and …, 2020 - Wiley Online Library
Oxygen is vital to the function of all tissues including the liver and lack of oxygen, that is,
hypoxia can result in both acute and chronic injuries to the liver in vivo and ex vivo …
hypoxia can result in both acute and chronic injuries to the liver in vivo and ex vivo …
Pre-clinical and clinical investigations of metabolic zonation in liver diseases: the potential of microphysiology systems
A Soto-Gutierrez, A Gough, LA Vernetti… - Experimental …, 2017 - journals.sagepub.com
The establishment of metabolic zonation within a hepatic lobule ascribes specific functions
to hepatocytes based on unique, location-dependent gene expression patterns. Recently …
to hepatocytes based on unique, location-dependent gene expression patterns. Recently …
In vitro functional models for human liver diseases and drug screening: beyond animal testing
Liver is one of the most important and complex organs in the human body, being
characterized by a sophisticated microarchitecture and responsible for key physiological …
characterized by a sophisticated microarchitecture and responsible for key physiological …
Measuring and regulating oxygen levels in microphysiological systems: Design, material, and sensor considerations
As microfabrication techniques and tissue engineering methods improve, microphysiological
systems (MPS) are being engineered that recapitulate complex physiological and …
systems (MPS) are being engineered that recapitulate complex physiological and …