Adapting a phage to combat phage resistance
E Laanto, K Mäkelä, V Hoikkala, JJ Ravantti… - Antibiotics, 2020 - mdpi.com
Phage therapy is becoming a widely recognized alternative for fighting pathogenic bacteria
due to increasing antibiotic resistance problems. However, one of the common concerns …
due to increasing antibiotic resistance problems. However, one of the common concerns …
Mucin induces CRISPR-Cas defense in an opportunistic pathogen
GM de Freitas Almeida, V Hoikkala, J Ravantti… - Nature …, 2022 - nature.com
Parasitism by bacteriophages has led to the evolution of a variety of defense mechanisms in
their host bacteria. However, it is unclear what factors lead to specific defenses being …
their host bacteria. However, it is unclear what factors lead to specific defenses being …
CRISPR Arrays Away from cas Genes
CRISPR-Cas systems typically consist of a CRISPR array and cas genes that are organized
in one or more operons. However, a substantial fraction of CRISPR arrays are not adjacent …
in one or more operons. However, a substantial fraction of CRISPR arrays are not adjacent …
Bacteriophage resistance affects Flavobacterium columnare virulence partly via mutations in genes related to gliding motility and the type IX secretion system
HMT Kunttu, A Runtuvuori-Salmela… - Applied and …, 2021 - Am Soc Microbiol
Increasing problems with antibiotic resistance have directed interest toward phage therapy
in the aquaculture industry. However, phage resistance evolving in target bacteria is …
in the aquaculture industry. However, phage resistance evolving in target bacteria is …
Prophages and past prophage-host interactions revealed by CRISPR spacer content in a fish pathogen
E Laanto, JJ Ravantti, LR Sundberg - Microorganisms, 2020 - mdpi.com
The role of prophages in the evolution, diversification, or virulence of the fish pathogen
Flavobacterium columnare has not been studied thus far. Here, we describe a functional …
Flavobacterium columnare has not been studied thus far. Here, we describe a functional …
Mucin induces CRISPR-Cas defence in an opportunistic pathogen
GMF Almeida, V Hoikkala, J Ravantti, N Rantanen… - bioRxiv, 2021 - biorxiv.org
Parasitism by bacteriophages has led to the evolution of a variety of defense mechanisms in
their host bacteria. However, it is unclear what factors lead to specific defenses being …
their host bacteria. However, it is unclear what factors lead to specific defenses being …
The Reverse Transcriptases associated with CRISPR-Cas systems: Phylogenetic relationships and functional characterization
A González-Delgado - 2021 - digibug.ugr.es
The objective of this thesis consisted of the characterization of novel groups of RTs linked to
CRISPR-Cas systems. An initial analysis of the different distribution of RTs in bacteria and …
CRISPR-Cas systems. An initial analysis of the different distribution of RTs in bacteria and …