[HTML][HTML] Ferritins as natural and artificial nanozymes for theranostics

B Jiang, L Fang, K Wu, X Yan, K Fan - Theranostics, 2020 - ncbi.nlm.nih.gov
Nanozymes are a class of nanomaterials with intrinsic enzyme-like characteristics which
overcome the limitations of natural enzymes such as high cost, low stability and difficulty to …

Redox-active metal ions and amyloid-degrading enzymes in Alzheimer's disease

N Kim, HJ Lee - International Journal of Molecular Sciences, 2021 - mdpi.com
Redox-active metal ions, Cu (I/II) and Fe (II/III), are essential biological molecules for the
normal functioning of the brain, including oxidative metabolism, synaptic plasticity …

Ferritin-based targeted delivery of arsenic to diverse leukaemia types confers strong anti-leukaemia therapeutic effects

C Wang, W Zhang, Y He, Z Gao, L Liu, S Yu… - Nature …, 2021 - nature.com
Trivalent arsenic (AsIII) is an effective agent for treating patients with acute promyelocytic
leukaemia, but its ionic nature leads to several major limitations like low effective …

A natural drug entry channel in the ferritin nanocage

B Jiang, X Chen, G Sun, X Chen, Y Yin, Y Jin, Q Mi… - Nano Today, 2020 - Elsevier
Ferritin, a widely expressed iron binding protein, has emerged as a promising drug delivery
vehicle due to its unique architecture, intrinsic tumor targeting property, and excellent …

[HTML][HTML] Bioconjugation of the gold drug auranofin to human ferritin yields a potent cytotoxin

L Cosottini, L Massai, V Ghini, S Zineddu, A Geri… - Journal of Drug Delivery …, 2023 - Elsevier
Ferritin may serve as a nanocarrier for the selective delivery of anticancer metallodrugs.
Here, we have prepared and characterized a well-defined conjugate between the gold drug …

Four‐fold channel‐nicked human ferritin nanocages for active drug loading and pH‐responsive drug release

B Ahn, SG Lee, HR Yoon, JM Lee, HJ Oh… - Angewandte …, 2018 - Wiley Online Library
Human ferritins are emerging platforms for non‐toxic protein‐based drug delivery, owing to
their intrinsic or acquirable targeting abilities to cancer cells and hollow cage structures for …

Ferritin nanocomposites for the selective delivery of photosensitizing ruthenium-polypyridyl compounds to cancer cells

L Conti, S Ciambellotti, GE Giacomazzo… - Inorganic Chemistry …, 2022 - pubs.rsc.org
Herein, we report on the successful encapsulation into human H-ferritin of two highly
charged Ru (II) polypyridyl complexes,[Ru (phen) 2L′] 2+(Ru1, with L′= 4, 4′-(2, 5, 8, 11 …

Unlocking the Power of Human Ferritin: Enhanced Drug Delivery of Aurothiomalate in A2780 Ovarian Cancer Cells

L Cosottini, A Geri, V Ghini, M Mannelli… - Angewandte …, 2024 - Wiley Online Library
Aurothiomalate (AuTM) is an FDA‐approved antiarthritic gold drug with unique anticancer
properties. To enhance its anticancer activity, we prepared a bioconjugate with human …

Chemistry at the protein–mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster

C Pozzi, S Ciambellotti… - Proceedings of the …, 2017 - National Acad Sciences
X-ray structures of homopolymeric L-ferritin obtained by freezing protein crystals at
increasing exposure times to a ferrous solution showed the progressive formation of a triiron …

A review on the cardioprotective mechanisms of metformin against doxorubicin

AH Ajzashokouhi, HB Bostan… - Human & …, 2020 - journals.sagepub.com
Doxorubicin (DOX) is an antineoplastic agent obtained from Streptomyces peucetius. It is
utilized in treating different kinds of cancers, such as leukemia, lymphoma, and lung, and …