Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic
instability results from mutations in DNA repair genes and drives cancer development, as …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Although thousands of long noncoding RNAs (lncRNAs) have been discovered, very little is
known about their mode of action. Here we functionally characterize an E2F1-regulated …

During tumour development cells sustain mutations that disrupt normal mechanisms
controlling proliferation. Remarkably, the Rb–E2f and MDM2–p53 pathways are both …

The retinoblastoma tumor suppressor, pRb, restricts cell-cycle progression mainly by
regulating members of the E2F-transcription-factor family. The Rb pathway is often …

The E2F1 transcription factor is a critical downstream target of the tumor suppressor pRB.
The retinoblastoma (RB) pathway is often inactivated in human tumors, resulting in …

Ataxia-telangiectasia mutated (ATM) is a high molecular weight protein serine/threonine
kinase that plays a central role in the maintenance of genomic integrity by activating cell …

Exposure to genotoxic agents is a major cause of human cancer, and cellular responses to
genotoxic stress are important defense mechanisms. These responses are very complex …

Background Genomic DNA copy number aberrations are frequent in solid tumors, although
the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to …

The protein p53 functions as a tumor suppressor and can trigger either cell cycle arrest or
apoptosis in response to DNA damage. We used Boolean network modeling and attractor …