Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

A Picca, RT Mankowski, JL Burman, L Donisi… - Nature Reviews …, 2018 - nature.com
Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for developing cardiovascular disease because of the …

Adenylate kinase and metabolic signaling in cancer cells

A Klepinin, S Zhang, L Klepinina… - Frontiers in …, 2020 - frontiersin.org
A hallmark of cancer cells is the ability to rewire their bioenergetics and metabolic signaling
circuits to fuel their uncontrolled proliferation and metastasis. Adenylate kinase (AK) is the …

Mitochondrial physiology

C Gourlay - bioenergetic communications, 2020 - kar.kent.ac.uk
Internal and external respiration (mt) Mitochondrial catabolic respiration JkO2 is the O2
consumption in the oxidation of fuel substrates (electron donors) and reduction of O2 …

Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network

L Klepinina, A Klepinin, L Truu, V Chekulayev, H Vija… - PLoS …, 2021 - journals.plos.org
The ability of butyrate to promote differentiation of cancer cells has important implication for
colorectal cancer (CRC) prevention and therapy. In this study, we examined the effect of …

Sensing and responding to energetic stress: Evolution of the AMPK network

PM Craig, CD Moyes, CMR LeMoine - Comparative Biochemistry and …, 2018 - Elsevier
AMP-activated protein kinase is an enzyme that mediates communication between cellular
energy status and diverse effector proteins, particularly those that play roles in determining …

Tubulin βII and βIII isoforms as the regulators of VDAC channel permeability in health and disease

M Puurand, K Tepp, N Timohhina, J Aid, I Shevchuk… - Cells, 2019 - mdpi.com
In recent decades, there have been several models describing the relationships between
the cytoskeleton and the bioenergetic function of the cell. The main player in these models is …

Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug …

N Li, H Li, Y Wang, L Cao, X Zhan - EPMA Journal, 2020 - Springer
Objective Energy metabolism abnormality is the hallmark in epithelial ovarian carcinoma
(EOC). This study aimed to investigate energy metabolism pathway alterations and their …

Mitochondrial respiratory states and rates

E Gnaiger, T Arnould, D Detraux… - MitoFit …, 2019 - researchportal.unamur.be
As the knowledge base and importance of mitochondrial physiology to human health
expands, the necessity for harmonizing the terminology concerning mitochondrial …

[HTML][HTML] On the role of tubulin, plectin, desmin, and vimentin in the regulation of mitochondrial energy fluxes in muscle cells

K Mado, V Chekulayev, I Shevchuk… - … of Physiology-Cell …, 2019 - journals.physiology.org
Mitochondria perform a central role in life and death of the eukaryotic cell. They are major
players in the generation of macroergic compounds and function as integrated signaling …

Stable isotope tracing uncovers reduced γ/β-ATP turnover and metabolic flux through mitochondrial-linked phosphotransfer circuits in aggressive breast cancer cells

A Klepinin, S Miller, I Reile, M Puurand… - Frontiers in …, 2022 - frontiersin.org
Changes in dynamics of ATP γ-and β-phosphoryl turnover and metabolic flux through
phosphotransfer pathways in cancer cells are still unknown. Using 18O phosphometabolite …