Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and
severely limits brain penetration of systemically administered drugs, resulting in ineffective …

Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …

Aging-related cellular and molecular processes including low-grade inflammation are major
players in the pathogenesis of cardiovascular disease (CVD) and Alzheimer's disease (AD) …

Cholesterol is a critical component of membrane bilayers where it plays key structural and
functional roles by regulating the activity of diverse signaling platforms and pathways …

The blood–brain barrier (BBB) precisely controls brain microenvironment and neural activity
by regulating substance transport into and out of the brain. However, it severely hinders drug …

Breast cancer brain metastases (BCBMs) are one of the most difficult malignancies to treat
due to the intracranial location and multifocal growth. Chemotherapy and molecular targeted …

Alzheimer's disease (AD), the most common cause of dementia, is a complex and
multifactorial disease involving genetic and environmental factors, with …

Brain metastases present mostly multifocal, infiltrative and co-opting growth with the blood-
brain barrier (BBB) remaining intact. The BBB, as the barrier of drug delivery to such lesions …

Defective degradation and clearance of amyloid-β as well as inflammation per se are crucial
players in the pathology of Alzheimer's disease (AD). A defective transport across the blood …