Biomarkers and detection platforms for human health and performance monitoring: a review

D Sim, MC Brothers, JM Slocik, AE Islam… - Advanced …, 2022 - Wiley Online Library
Human health and performance monitoring (HHPM) is imperative to provide information
necessary for protecting, sustaining, evaluating, and improving personnel in various …

The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour

A Farzi, F Reichmann, P Holzer - Acta Physiologica, 2015 - Wiley Online Library
Neuropeptide Y (NPY), one of the most abundant peptides in the nervous system, exerts its
effects via five receptor types, termed Y 1, Y 2, Y 4, Y 5 and Y 6. NPY's pleiotropic functions …

The neuropeptide Y system: pathophysiological and therapeutic implications in obesity and cancer

L Zhang, MS Bijker, H Herzog - Pharmacology & therapeutics, 2011 - Elsevier
The neuropeptide Y (NPY) system–comprising of neuropeptide Y, peptide YY, pancreatic
polypeptide and the corresponding Y receptors through which they act (Y1, Y2, Y4, Y5 and …

Metabolism of peptide drugs and strategies to improve their metabolic stability

JF Yao, H Yang, YZ Zhao, M Xue - Current drug metabolism, 2018 - ingentaconnect.com
Background: Despite the therapeutic use of peptides is limited because of their metabolism
in vivo, there are no systematic reviews explaining degradation of peptides by peptidases …

NPY receptors as potential targets for anti‐obesity drug development

E Yulyaningsih, L Zhang, H Herzog… - British journal of …, 2011 - Wiley Online Library
The neuropeptide Y system has proven to be one of the most important regulators of feeding
behaviour and energy homeostasis, thus presenting great potential as a therapeutic target …

NPY and gene therapy for epilepsy: how, when,... and Y

S Cattaneo, G Verlengia, P Marino… - Frontiers in molecular …, 2021 - frontiersin.org
Neuropeptide Y (NPY) is a neuropeptide abundantly expressed in the mammalian central
and peripheral nervous system. NPY is a pleiotropic molecule, which influences cell …

Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation

K Singer, DL Morris, KE Oatmen, T Wang… - PloS one, 2013 - journals.plos.org
Neuropeptide Y (NPY) is induced in peripheral tissues such as adipose tissue with obesity.
The mechanism and function of NPY induction in fat are unclear. Given the evidence that …

Human proline specific peptidases: A comprehensive analysis

YE Dunaevsky, VF Tereshchenkova, B Oppert… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Abstract Background Proline specific peptidases (PSPs) are a unique group of enzymes that
specifically cleave bonds formed by a proline residue. The study of PSPs is important due to …

Neuropeptides: metabolism to bioactive fragments and the pharmacology of their receptors

M Hallberg - Medicinal Research Reviews, 2015 - Wiley Online Library
The proteolytic processing of neuropeptides has an important regulatory function and the
peptide fragments resulting from the enzymatic degradation often exert essential …

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl-and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents

C Fischer, T Lamer, W Wang, SMK McKinnie… - European journal of …, 2019 - Elsevier
Apelins are human peptide hormones with various physiological activities, including the
moderation of cardiovascular, renal, metabolic and neurological function. Their potency is …