Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic
producers are an integral part of the growing antibiotic resistance threat. The origins of …

Tetracyclines have been foundational antibacterial agents for more than 70 years. Renewed
interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis …

Although tetracyclines are an important class of antibiotics for use in agriculture and the
clinic, their efficacy is threatened by increasing resistance. Resistance to tetracyclines can …

Metabolic control is mediated by the dynamic assemblies and function of multiple redox
enzymes. A key element in these assemblies, the P450 oxidoreductase (POR), donates …

Flavin-dependent monooxygenases catalyze a wide variety of redox reactions in important
biological processes and are responsible for the synthesis of highly complex natural …

Covering: 2011 to 2021 Structural division of natural naphthalenoid ansamycins, regarding
the type of the core and length of the ansa chain, and their biosynthetic pathways in …

Antibacterial resistance is a prominent issue with monotherapy often leading to treatment
failure in serious infections. Many mechanisms can lead to antibacterial resistance including …

Rifamycin monooxygenases (Rox) are present in a variety of environmental bacteria and are
associated with decomposition of the clinically utilized antibiotic rifampin. Here we report the …

Antimicrobial resistance represents a major threat to human health and knowledge of the
underlying mechanisms is therefore vital. Here, we report the discovery and characterization …