Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1–based therapies
M Elashoff, AV Matveyenko, B Gier, R Elashoff… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Glucagon-like peptide-1− based therapy is gaining widespread
use for type 2 diabetes, although there are concerns about risks for pancreatitis and …
use for type 2 diabetes, although there are concerns about risks for pancreatitis and …
Data mining techniques in pharmacovigilance: analysis of the publicly accessible FDA adverse event reporting system (AERS)
E Poluzzi, E Raschi, C Piccinni… - Data mining applications …, 2012 - books.google.com
Drug use in medicine is based on a balance between expected benefits (already
investigated before marketing authorization) and possible risks (ie, adverse effects), which …
investigated before marketing authorization) and possible risks (ie, adverse effects), which …
T-cell non-Hodgkin's lymphomas reported to the FDA AERS with tumor necrosis factor-alpha (TNF-α) inhibitors: results of the REFURBISH study
P Deepak, H Sifuentes, M Sherid… - Official journal of the …, 2013 - journals.lww.com
OBJECTIVES: The risk of non-Hodgkin's lymphoma (NHL) with tumor necrosis factor alpha
(TNF-α) inhibitors is unclear, whether related to concomitant thiopurines usage or due to the …
(TNF-α) inhibitors is unclear, whether related to concomitant thiopurines usage or due to the …
Antibiotic-induced liver toxicity: mechanisms, clinical features and causality assessment
M Robles, E Toscano, J Cotta… - Current drug …, 2010 - benthamdirect.com
Antibiotics are the therapeutic agents most often associated with hepatotoxicity. However,
this is mainly due to the widespread prescription of these drugs. The relative risk of antibiotic …
this is mainly due to the widespread prescription of these drugs. The relative risk of antibiotic …
Hepatotoxicity of antibiotics: a review and update for the clinician
JG Stine, JH Lewis - Clinics in Liver Disease, 2013 - liver.theclinics.com
Collectively, the various classes of antibiotics are a leading cause of drug-induced liver
injury (DILI). 1, 2 Indeed, among causes of nonacetaminophen-related acute DILI …
injury (DILI). 1, 2 Indeed, among causes of nonacetaminophen-related acute DILI …
[HTML][HTML] Predicting drug-induced liver injury: The importance of data curation
Drug-induced liver injury (DILI) is a major issue for both patients and pharmaceutical
industry due to insufficient means of prevention/prediction. In the current work we present a …
industry due to insufficient means of prevention/prediction. In the current work we present a …
Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data
X Zhu, NL Kruhlak - Toxicology, 2014 - Elsevier
Drug-induced liver injury (DILI) is one of the most common drug-induced adverse events
(AEs) leading to life-threatening conditions such as acute liver failure. It has also been …
(AEs) leading to life-threatening conditions such as acute liver failure. It has also been …
Predicting Drug-Induced Cholestasis with the Help of Hepatic TransportersAn in Silico Modeling Approach
E Kotsampasakou, GF Ecker - Journal of chemical information and …, 2017 - ACS Publications
Cholestasis represents one out of three types of drug induced liver injury (DILI), which
comprises a major challenge in drug development. In this study we applied a two-class …
comprises a major challenge in drug development. In this study we applied a two-class …
Drug-induced liver injury: what was new in 2008?
G Liss, JH Lewis - Expert Opinion on Drug Metabolism & …, 2009 - Taylor & Francis
Background: Given the number of publications appearing annually regarding drug-induced
liver injury (DILI), there remains a need to concisely summarize each year's new crop of …
liver injury (DILI), there remains a need to concisely summarize each year's new crop of …
The role of disproportionality analysis of pharmacovigilance databases in safety regulatory actions: a systematic review
P Dias, A Penedones, C Alves, CF Ribeiro… - Current drug …, 2015 - ingentaconnect.com
Introduction: Disproportionality analysis (DA) of adverse drug reactions spontaneous
reporting (SR) databases is used to identify signals of disproportionate reporting (SDR). The …
reporting (SR) databases is used to identify signals of disproportionate reporting (SDR). The …