Redox equilibria and the modulation of redox signalling play crucial roles in physiological
processes. Overproduction of reactive oxygen species (ROS) disrupts the body's antioxidant …

Alzheimer's disease (AD) is the most common chronic neurodegenerative disease
worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental …

Background. Alzheimer's disease (AD) is the most common cause of dementia in elderly
patients. Recently, several studies have shown that inflammation and oxidative stress …

Exposure to ambient fine particulate matter (PM 2.5) is associated with neurodegenerative
diseases. Mitochondrion is key to brain degeneration. However, the underlying mechanism …

Mitochondrial DNA copy number (mtDNA-CN) is a proxy for mitochondrial function and is
associated with aging-related diseases. However, it is unclear how mtDNA-CN measured in …

Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …

Cognitive impairment is commonly found in the elderly population. Evidence suggests that
mitochondrial function in lymphocytes are potential biomarkers in the progression of …

Background Blood-derived mitochondrial DNA copy number (mtDNA-CN) is a proxy
measurement of mitochondrial function in the peripheral and central systems. Abnormal …

Several theories have been postulated, trying to explain why and how living organisms age.
Despite some controversies and still huge open questions, a growing body of evidence …

Methylation levels of the mitochondrial displacement loop (D-loop) region have been
reported to be altered in the brain and blood of Alzheimer's disease (AD) patients. Moreover …