Mu opioid receptor agonists are among the most powerful analgesic medications but also
among the most addictive. The current opioid crisis has energized a quest to develop opioid …

▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-
spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of …

Selective PCR amplification of human and mouse genomic DNAs with oligonucleotides
encoding highly conserved regions of the δ-opioid and somatostatin receptors generated a …

Morphine produces analgesia at opiate receptors expressed in nociceptive circuits. μ, δ, and
κ opiate receptor subtypes are expressed in circuits that can modulate nociception and …

It is now clear that opioid receptors participate in the function of the cells of the immune
system, and evidence suggests that opioids modulate both innate and acquired immune …

The advance in our understanding of the biogenesis of various endogenous opioid
peptides, their anatomical distribution, and the characteristics of the multiple receptors with …

The endogenous opioid peptides have multiple physiological actions at both a central and
peripheral level which are mediated by 3 main classes of opioid receptors, μ, δ and κ. The …

This review gives a historical perspective, summarizing approximately 25 years of research
on opioids. The “typical” opioid peptides produced in the brain,“atypical” opioids encrypted …

Opiates like morphine and endogenous opioid peptides exert their pharmacological and
physiological effects through binding to their endogenous receptors, opioid receptors. The …

Recently, antisera that recognize unique epitopes of the cloned mu-, delta-, and kappa-
opioid, receptors (MOR, DOR, KOR, respectively) have been developed. In the present study …